Article
Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A.
The New England journal of medicine - 29 Sept 1994
Lips C J, Landsvater R M, Höppener J W, Geerdink R A, Blijham G, van Veen J M, van Gils A P, de Wit M J, Zewald R A, Berends M J
Abstract excerpt
BACKGROUND: Multiple endocrine neoplasia type 2A (MEN-2A) is characterized by medullary thyroid carcinoma in combination with pheochromocytoma and sometimes parathyroid adenoma. Missense mutations in the RET proto-oncogene are associated with MEN-2A. Their detection by DNA analysis allows the ide...
Topics
- Adolescent
- Adrenal Gland Neoplasms
- Adult
- Base Sequence
- Calcitonin
- Child
- Child, Preschool
- DNA Mutational Analysis
- DNA Probes
- Female
- Genetic Carrier Screening
- Genetic Linkage
- Genetic Markers
- Humans
- Male