Article
[The direct gene test in familial medullary thyroid gland carcinoma and in MEN syndromes. Detection of mutations in the ret proto-oncogene saves screening studies].
Fortschritte der Medizin - 20 Dec 1995
Stuhrmann M
Abstract excerpt
Multiple endocrine neoplasias, type 2A and type 2B (MEN2A, MEN2B), and familial medullary thyroid carcinoma (FMTC) have an autosomal dominant mode of inheritance. The risk of passing on the disease is almost 50%. Early diagnosis and surgical intervention largely prevents aggressive metastasis of...
Topics
- Adolescent
- Adult
- Aged
- Carcinoma, Medullary
- Child
- Child, Preschool
- DNA Mutational Analysis
- Drosophila Proteins
- Female
- Genes, Dominant
- Genetic Testing
- Humans
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 2a
- Multiple Endocrine Neoplasia Type 2b