Article
Application of linked DNA markers to screening families with multiple endocrine neoplasia type 2A.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Apr 1990
Telenius H, Mathew C G, Nakamura Y, Easton D F, Clark J, Neumann H P, Ziegler W H, Schinzel A, Ponder B A
Abstract excerpt
There now exists a set of tightly linked markers to the gene causing multiple endocrine neoplasia type 2A. In this report we discuss the use of these markers for early and accurate prediction of gene carrier status in three different families. Factors that influence the probability of obtaining useful information with DNA markers are available family size, in particular the number of available affected...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- DNA, Neoplasm
- Female
- Genetic Carrier Screening
- Genetic Linkage
- Genetic Markers
- Genetic Testing