Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2.

doi:10.1016/j.jpedsurg.2006.10.005

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Article

Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2.

Journal of pediatric surgery - 1 Feb 2007

Moore Samuel W, Appfelstaedt Justus, Zaahl Monique G

Abstract excerpt

UNLABELLED: The ability to predict the risk of MEN2 and medullary thyroid carcinoma (MTC) by genetic RET proto-oncogene analysis has provided an essential tool in identifying patients in whom thyroid cancer can be prevented by prophylactic thyroidectomy but emphasizes the need for clear policy guidelines. Children of families with RET cysteine mutations (exons 10, 11, 13, and 16) may develop early metastatic...

Topics

Adult
Alleles
Carcinoma, Medullary
Child, Preschool
Cohort Studies
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Genetic Testing
Genotype
Heterozygote
Humans
Incidence
Infant
Male
Multiple Endocrine Neoplasia Type 2a
Pedigree
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 17270543
DOI: 10.1016/j.jpedsurg.2006.10.005

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