Article
A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.
European journal of clinical investigation - 1 Jun 1992
Pociot F, Mølvig J, Wogensen L, Worsaae H, Nerup J
Abstract excerpt
In the present study we searched for restriction fragment length polymorphisms (RFLP) in the human interleukin-1 beta (IL-1 beta) gene and for correlations to monocyte (Mo) function in non-related healthy donors and insulin-dependent diabetic patients. We demonstrated a diallelic polymorphism with the restriction enzyme TaqI consisting of fragments of 9.4 kb and 13.4 kb. No differences in allele or genotype...
Topics
- Adolescent
- Adult
- Alleles
- Deoxyribonucleases, Type II Site-Specific
- Diabetes Mellitus, Type 1
- Genotype
- Humans
- In Vitro Techniques
- Interleukin-1
- Male
- Monocytes