Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.

European journal of clinical investigation - 1 Jun 1992

Pociot F, Mølvig J, Wogensen L, Worsaae H, Nerup J

Abstract excerpt

In the present study we searched for restriction fragment length polymorphisms (RFLP) in the human interleukin-1 beta (IL-1 beta) gene and for correlations to monocyte (Mo) function in non-related healthy donors and insulin-dependent diabetic patients. We demonstrated a diallelic polymorphism with the restriction enzyme TaqI consisting of fragments of 9.4 kb and 13.4 kb. No differences in allele or genotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles
Share to Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genotype

Share to In Vitro Techniques

Share to Monocytes

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1353022
DOI: 10.1111/j.1365-2362.1992.tb01480.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.PMID 1353022Read ↗

Monocyte function in IDDM patients and healthy individuals.Semantic proximity Read ↗

A common polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene regulatory region influences MCP-1 expression and function of isolated human pancreatic islets.Semantic proximity Read ↗

A rare allele combination of the interleukin-1 gene complex is associated with high interleukin-1 beta plasma levels in healthy individuals.Semantic proximity Read ↗

Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein.Semantic proximity Read ↗

A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion.Semantic proximity Read ↗

IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein.Semantic proximity Read ↗

Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist.Semantic proximity Read ↗

Interleukin 10 secretion in relation to human IL-10 locus haplotypes.Semantic proximity Read ↗

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphismSemantic proximity Read ↗

Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease.Semantic proximity Read ↗

Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.