Article
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.
European journal of immunology - 1 Jan 1993
Pociot F, Briant L, Jongeneel C V, Mölvig J, Worsaae H, Abbal M, Thomsen M, Nerup J, Cambon-Thomsen A
Abstract excerpt
We have investigated the correlation between different tumor necrosis factor (TNF) and class II major histocompatibility complex alleles in the lipopolysaccharide- or phytohemagglutinin-induced secretion of TNF-alpha and TNF-beta by human monocytes and peripheral blood mononuclear cells in 87 unr...
Topics
- Adolescent
- Adult
- Alleles
- Diabetes Mellitus, Type 1
- Genes, MHC Class II
- Genetic Linkage
- Genotype
- HLA-DR Antigens
- Haplotypes
- Heterozygote
- Humans