Article
A common polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene regulatory region influences MCP-1 expression and function of isolated human pancreatic islets.
Transplantation proceedings - 1 Jan 2000
Del Guerra S, D'Aleo V, Gualtierotti G, Filipponi F, Boggi U, De Simone P, Vistoli F, Del Prato S, Marchetti P, Lupi R
Abstract excerpt
BACKGROUND AND AIMS: Islet transplantation is an attractive approach to treat type 1 diabetic patients. However, suboptimal islet engraftment still represents an unsolved problem. It has been shown that human islets release monocyte chemoattractant protein-1 (MCP-1), one of the most powerful macrophage chemokines, which may impair the fate of the transplant. The aim of this study was to evaluate the presence and...
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