Article
Hemophilia A carrier detection by restriction fragment length polymorphism analysis and discriminant analysis based on ELISA of factor VIII and vWf.
The Journal of laboratory and clinical medicine - 1 Jun 1992
Poon M C, Hoar D I, Low S, Pon J K, Anand S, Sinclair G D
Abstract excerpt
We performed carrier determination on female subjects from 32 hemophilia A kindreds with a combination of restriction fragment length polymorphism analysis and discriminant analysis of factor VIII antigen and von Willebrand factor antigen analyzed by enzyme-linked immunosorbent assay. Subjects included 25 obligate carriers, 30 at-risk female subjects from 19 kindreds each with two or more male subjects, with...
Topics
- DNA
- DNA Restriction Enzymes
- Discriminant Analysis
- Enzyme-Linked Immunosorbent Assay
- Factor VIII
- Female
- Genetic Carrier Screening
- Hemophilia A
- Humans
- Immunoglobulins
- Introns