Utility of factor VIII and factor VIII to von Willebrand factor ratio in identifying 277 unselected carriers of hemophilia A

Abstract excerpt

Hemophilia A (HA) is an X-linked bleeding disorder caused by a mutation in the factor VIII (FVIII) gene. When a male is diagnosed with hemophilia his mother may or may not be a carrier. Mutation analysis is the gold standard to identify female carriers. Unfortunately, the causative mutation may be unknown or genetic testing may not be available. Therefore, an alternative tool to determine carrier status would be...

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