Article
A DNA polymorphism for LCAT is associated with altered LCAT activity and high density lipoprotein size distributions in baboons.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jun 1992
Rainwater D L, Blangero J, Hixson J E, Birnbaum S, Mott G E, VandeBerg J L
Abstract excerpt
A polymorphic Pvu II site was mapped to intron 5 of LCAT, the gene encoding baboon lecithin: cholesterol acyltransferase (LCAT). In a study of 83 baboons, heterozygous baboons (Pv1/Pv2) had significantly higher LCAT enzyme activity levels than did baboons homozygous for the more common allele (Pv...
Topics
- Animals
- Apolipoprotein A-I
- Base Sequence
- Cholesterol
- Cholesterol, HDL
- Chromosome Mapping
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genotype
- Introns
- Lipoproteins, HDL
- Male
- Molecular Sequence Data
- Papio
- Phosphatidylcholine-Sterol O-Acyltransferase
- Polymorphism, Restriction Fragment Length