Article
Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons.
Human molecular genetics - 15 May 2004
Wang Qian-fei, Liu Xin, O'Connell Jeff, Peng Ze, Krauss Ronald M, Rainwater David L, VandeBerg John L, Rubin Edward M, Cheng Jan-Fang, Pennacchio Len A
Abstract excerpt
Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however, whether independently arising polymorphisms in orthologous regions of non-human primates leads to similar variation in a quantitative trait found in both species. To explore this paradigm, we studied a baboon...
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