Article
Characteristic, polymorphism and expression distribution of LCAT gene in a Mongolian gerbil model for hyperlipidemia.
Experimental and molecular pathology - 1 Oct 2014
Liu Yue huan, Wu Jiu sheng, Wang Zhi yuan, Yu Chen huan, Ying Hua zhong, Xu Ning ying
Abstract excerpt
This study aims to evaluate the genetic basis and activity of lecithin cholesterol acyltransferase (LCAT) in a novel Mongolian gerbil model for hyperlipidemia. Gerbils may be susceptible to high fat and cholesterol (HF/HC) diets, which can rapidly lead to the development of hyperlipidemia. Approximately 10-30% of gerbils that are over 8months old and fed controlled diets spontaneously develop hyperlipidemia....
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