Article
p53 mutations in spontaneously immortalized 3T12 but not 3T3 mouse embryo cells.
Oncogene - 1 May 1992
Rittling S R, Denhardt D T
Abstract excerpt
We have asked whether p53 mutations are involved in the process of spontaneous immortalization of mouse embryo cells. Cells from Swiss mouse embryos were used to prepare 3T3 and 3T12 lines according to the protocol of Todaro & Green [(1963). J. Cell Biol., 17, 299-313]. After the cells emerged fr...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Cell Line, Transformed
- Cellular Senescence
- Cloning, Molecular
- Genes, p53
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Precipitin Tests