Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras.

doi:10.1016/0167-4781(91)90209-5

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Article

Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras.

Biochimica et biophysica acta - 2 Dec 1991

Eizenberg O, Oren M

Abstract excerpt

Genes whose expression patterns are altered in a cell line immortalized by mutant p53 were isolated by differential screening of a cDNA library. Levels of alpha 1 (I) collagen mRNA were reduced in the majority of immortalized cell lines which greatly overproduced the transfected mutant p53. This may reflect a co-selection during the establishment of the cell lines, rather than a direct effect of p53 on alpha 1...

Topics

Animals
Base Sequence
Blotting, Northern
Cell Transformation, Neoplastic
Collagen
Down-Regulation
Electrophoresis, Gel, Two-Dimensional
Genes, p53
Genes, ras
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Precursors

Proto-Oncogene Proteins p21(ras)

Rats

Rats, Inbred F344

Sequence Alignment

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1756178
DOI: 10.1016/0167-4781(91)90209-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1756178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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