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Article

Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras.

Biochimica et biophysica acta - 2 Dec 1991

Eizenberg O, Oren M

Abstract excerpt

Genes whose expression patterns are altered in a cell line immortalized by mutant p53 were isolated by differential screening of a cDNA library. Levels of alpha 1 (I) collagen mRNA were reduced in the majority of immortalized cell lines which greatly overproduced the transfected mutant p53. This may reflect a co-selection during the establishment of the cell lines, rather than a direct effect of p53 on alpha 1...

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PMID: 1756178
DOI: 10.1016/0167-4781(91)90209-5

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