Article
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11.
BMC genomics - 6 Jul 2005
De Preter Katleen, Vandesompele Jo, Menten Björn, Carr Philippa, Fiegler Heike, Edsjö Anders, Carter Nigel P, Yigit Nurten, Waelput Wim, Van Roy Nadine, Bader Scott, Påhlman Sven, Speleman Frank
Abstract excerpt
BACKGROUND: Loss of chromosome 11q defines a subset of high-stage aggressive neuroblastomas. Deletions are typically large and mapping efforts have thus far not lead to a well defined consensus region, which hampers the identification of positional candidate tumour suppressor genes. In a previous study, functional evidence for a neuroblastoma suppressor gene on chromosome 11 was obtained through microcell...
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