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Article

Novel genetic markers of rheumatoid arthritis in Chilean patients, by DR serotyping and restriction fragment length polymorphism analysis.

Arthritis and rheumatism - 1 Mar 1992

González A, Nicovani S, Massardo L, Bull P, Rodríguez L, Jacobelli S

Abstract excerpt

OBJECTIVE: The analysis of genetic markers of rheumatoid arthritis (RA) in a population in which the DR4 serotype is not strongly associated with the disease. METHODS: Chilean RA patients (56 seropositive and 22 seronegative) and 141 controls were studied by serotyping. Southern blot analysis of Bam HI restriction fragment length polymorphism (RFLP) was done in genomic DNA from 46 patients with seropositive RA,...

Topics

Adult
Arthritis, Rheumatoid
Blotting, Southern
Chile
Genetic Markers
Genetic Predisposition to Disease
HLA-DR Antigens
Humans
Middle Aged
Nucleic Acid Hybridization
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1346960
DOI: 10.1002/art.1780350306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1346960-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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