Article
Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.
Gene - 28 Apr 2004
Musio Antonio, Mariani Tullio, Montagna Cristina, Zambroni Desirèe, Ascoli Cesare, Ried Thomas, Vezzoni Paolo
Abstract excerpt
Roberts syndrome is an autosomal recessive disorder characterised primarily by symmetric reduction of all limbs and growth retardation. Patients have been reported to have premature separation of heterochromatin regions of many chromosomes and abnormalities in cell cycle. Given the rarity of the syndrome, the linkage analysis approach is not suitable to identify the responsible gene. In this work, a cell line...
Topics
- Abnormalities, Multiple
- Aneuploidy
- Caffeine
- Cell Cycle
- Cell Division
- Cell Line
- Centromere
- Chromosomal Proteins, Non-Histone
- Chromosome Aberrations
- DNA-Binding Proteins
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Growth Disorders