Article
Toxin resistance and reduced secretion in a mouse L-cell mutant defective in herpes virus propagation.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2000
Michaelis C, Banfield B W, Gruenheid S, Tsang Y, Lippe R, Jefferies W A, Wattenberg B W, Tufaro F
Abstract excerpt
The mouse L-cell mutant gro29 was selected originally for its inability to propagate herpes simplex virus; it shows severe defects in virus egress and the transport and processing of viral glycoproteins after infection. In this report, we show that uninfected gro29 cells display pleiotropic changes in protein secretion, oligosaccharide processing, and sensitivity to the toxins ricin and modeccin. Specifically,...
Topics
- Animals
- Biological Transport
- CHO Cells
- Cell-Free System
- Cricetinae
- Drug Resistance
- Glycoproteins
- Golgi Apparatus
- L Cells
- Lectins
- Mice