A toxin-resistant mouse L-cell mutant defective in protein transport along the secretory pathway.

doi:10.1002/jcp.1041470205

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Article

A toxin-resistant mouse L-cell mutant defective in protein transport along the secretory pathway.

Journal of cellular physiology - 1 May 1991

Laurie S M, Robbins A R

Abstract excerpt

Using methods designed for isolation of mutants defective in receptor-mediated endocytosis, a novel L-cell mutant was obtained that exhibits resistance to three different protein toxins as well as alterations in secretion. This mutant, LEFIC, is resistant to modeccin, Pseudomonas exotoxin, and ricin. These toxins, which enter the cytoplasm via receptor-mediated endocytosis, are thought to penetrate into cells at...

Topics

ADP Ribose Transferases
Animals
Bacterial Toxins
Biological Transport
Drug Resistance
Endocytosis
Exotoxins
Fibronectins
GTP-Binding Proteins
L Cells
Lectins
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Phenotype

Plant Lectins

Protein Processing, Post-Translational

Proteins

Source

Open in PubMed

Identifiers

PMID: 1645740
DOI: 10.1002/jcp.1041470205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645740-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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