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Article

A toxin-resistant mouse L-cell mutant defective in protein transport along the secretory pathway.

Journal of cellular physiology - 1 May 1991

Laurie S M, Robbins A R

Abstract excerpt

Using methods designed for isolation of mutants defective in receptor-mediated endocytosis, a novel L-cell mutant was obtained that exhibits resistance to three different protein toxins as well as alterations in secretion. This mutant, LEFIC, is resistant to modeccin, Pseudomonas exotoxin, and ricin. These toxins, which enter the cytoplasm via receptor-mediated endocytosis, are thought to penetrate into cells at...

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PMID: 1645740
DOI: 10.1002/jcp.1041470205

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