Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model.

doi:10.1128/JVI.03406-12

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Article

Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model.

Journal of virology - 1 Apr 2013

Farrell Helen E, Abraham Alexander M, Cardin Rhonda D, Mølleskov-Jensen Ann-Sofie, Rosenkilde Mette M, Davis-Poynter Nicholas

Abstract excerpt

The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and...

Topics

Analysis of Variance
Animals
COS Cells
Chlorocebus aethiops
Cytomegalovirus
HEK293 Cells
Humans
Luciferases
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Octoxynol

Phenotype

Receptors, Chemokine

Receptors, G-Protein-Coupled

Salivary Glands

Signal Transduction

Viral Proteins

Source

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Identifiers

PMID: 23345521
DOI: 10.1128/JVI.03406-12
PMCID: PMC3624218

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