Genetic implications for long-term survivors of childhood cancer.

Abstract excerpt

The author reviews current findings regarding inherited cancer predisposition and childhood cancer and proposes development of genetic services for long-term survivors of childhood cancer. Overall, it is suggested that relatively rare germline mutations in the tumor suppressor genes, Rb, p53, and WT1, may have important implications for long-term survivors relevant to familial cancer, second malignant neoplasms,...

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