Article
A review of inherited cancer syndromes and their relevance to oral squamous cell carcinoma.
Oral oncology - 1 Jan 2001
Prime S S, Thakker N S, Pring M, Guest P G, Paterson I C
Abstract excerpt
This paper examines the genetic defects associated with inherited cancer syndromes and their relevance to oral cancer. Tumour suppressor genes are now thought of as either gatekeepers or caretakers according to whether they control cell growth directly by inhibiting cell proliferation and/or promoting cell death (gatekeepers) or whether they maintain the integrity of the genome by DNA repair mechanisms...
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