Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spectrum of mutations produced by specific types of restriction enzyme-induced double-strand breaks.

Mutagenesis - 1 Nov 1992

Winegar R A, Lutze L H, Rufer J T, Morgan W F

Abstract excerpt

Rejoining of DNA double-strand breaks (DSB) plays a central role in the various processes leading to DNA rearrangements. We have analyzed DNA alterations induced by restriction enzymes that produce DSB with specific types of ends. Restriction enzymes were electroporated into a human lymphoblastoid cell line that stably maintains pHAZE, an EBV-based vector containing the lacZ gene. After allowing time for DSB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genetic Vectors

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 1335541
DOI: 10.1093/mutage/7.6.439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spectrum of mutations produced by specific types of restriction enzyme-induced double-strand breaks.PMID 1335541Read ↗

Noncomplementary DNA double-strand-break rejoining in bacterial and human cells.Semantic proximity Read ↗

Engineering novel restriction endonucleases: principles and applications.Semantic proximity Read ↗

Type II restriction of 2-aminoadenine (dZ) modified DNA and production of dZ-modified plasmid in <i>E. coli</i>Semantic proximity Read ↗

EcoKI with an amino acid substitution in any one of seven DEAD-box motifs has impaired ATPase and endonuclease activities.Semantic proximity Read ↗

Chromosomal aberrations induced by double strand DNA breaks.Semantic proximity Read ↗

Restriction endonuclease-catalyzed cleavage of DNA stimulates subsequent polymerase chain reaction and enables discrimination between normal and mutant K-RAS alleles.Semantic proximity Read ↗

Capture of DNA sequences at double-strand breaks in mammalian chromosomes.Semantic proximity Read ↗

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences.Semantic proximity Read ↗

Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.Semantic proximity Read ↗

Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway.Semantic proximity Read ↗

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity.Semantic proximity Read ↗

Effects of mutations in phage restriction sites during escape from restriction-modification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.