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Article

Spectrum of mutations produced by specific types of restriction enzyme-induced double-strand breaks.

Mutagenesis - 1 Nov 1992

Winegar R A, Lutze L H, Rufer J T, Morgan W F

Abstract excerpt

Rejoining of DNA double-strand breaks (DSB) plays a central role in the various processes leading to DNA rearrangements. We have analyzed DNA alterations induced by restriction enzymes that produce DSB with specific types of ends. Restriction enzymes were electroporated into a human lymphoblastoid cell line that stably maintains pHAZE, an EBV-based vector containing the lacZ gene. After allowing time for DSB...

Topics

Base Sequence
Binding Sites
Cell Line
DNA
DNA Damage
DNA Restriction Enzymes
Escherichia coli
Gene Rearrangement
Genetic Vectors
Herpesvirus 4, Human
Humans
Lac Operon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenicity Tests

Mutation

Source

Identifiers

PMID: 1335541
DOI: 10.1093/mutage/7.6.439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1335541-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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