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Article

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity.

Carcinogenesis - 1 Mar 1998

Izumi T, Mitra S

Abstract excerpt

AP-endonuclease (APE) plays a central role in the base excision repair process for oxidative and alkylation damage in DNA. The major human APE with 318 amino acid residues possesses transcriptional regulatory activities for which the N-terminal region was found to be essential. Systematic deletion studies of both amino and carboxyl termini of the human APE have shown that the carboxyl termini residues are...

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PMID: 9525290
DOI: 10.1093/carcin/19.3.525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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