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Article

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity.

Carcinogenesis - 1 Mar 1998

Izumi T, Mitra S

Abstract excerpt

AP-endonuclease (APE) plays a central role in the base excision repair process for oxidative and alkylation damage in DNA. The major human APE with 318 amino acid residues possesses transcriptional regulatory activities for which the N-terminal region was found to be essential. Systematic deletio...

Topics

Carbon-Oxygen Lyases
DNA Damage
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase
Deoxyribonuclease IV (Phage T4-Induced)
Escherichia coli
Escherichia coli Proteins
Humans
Oxidation-Reduction
Phenotype
Recombinant Proteins
Sequence Deletion

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Transcription, Genetic

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Identifiers

PMID: 9525290
DOI: 10.1093/carcin/19.3.525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9525290-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity.PMID 9525290Read ↗

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