Article
PC12 cells release stimulatory factors after transfection with beta/A4-C-terminal DNA of the Alzheimer amyloid precursor protein.
Molecular and chemical neuropathology - 1 Jan 2000
Majocha R E, Tate B, Marotta C A
Abstract excerpt
The beta/A4 region of the amyloid precursor protein (APP) accumulates in brains of victims of Alzheimer disease (AD) where it is a major component of senile plaques. We examined the pathophysiological consequences of overexpression of the beta/A4-C-terminal DNA in PC12 cells. Serum-free condition...
Topics
- Adsorption
- Amyloid beta-Protein Precursor
- Animals
- Base Sequence
- Blotting, Southern
- Cell Adhesion
- Cell Differentiation
- Culture Media, Conditioned
- DNA
- Immune Adherence Reaction
- Molecular Sequence Data
- PC12 Cells
- Phenotype
- Transfection