Article
An information-intensive approach to the molecular pharmacology of cancer.
Science (New York, N.Y.) - 17 Jan 1997
Weinstein J N, Myers T G, O'Connor P M, Friend S H, Fornace A J, Kohn K W, Fojo T, Bates S E, Rubinstein L V, Anderson N L, Buolamwini J K, van Osdol W W, Monks A P, Scudiero D A, Sausville E A, Zaharevitz D W, Bunow B, Viswanadhan V N, Johnson G S, Wittes R E, Paull K D
Abstract excerpt
Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory concentration (GI50) for any single cell line is simply an index of cytotoxicity or cytostasis, but the patterns of 60 such GI50...
Topics
- Algorithms
- Antineoplastic Agents
- Cluster Analysis
- Computational Biology
- Computer Communication Networks
- Databases, Factual
- Drug Screening Assays, Antitumor
- Genes, p53
- Humans
- Molecular Structure
- Mutation
- Software
- Tumor Cells, Cultured