Article
An information-intensive approach to the molecular pharmacology of cancer.
Science (New York, N.Y.) - 17 Jan 1997
Weinstein J N, Myers T G, O'Connor P M, Friend S H, Fornace A J, Kohn K W, Fojo T, Bates S E, Rubinstein L V, Anderson N L, Buolamwini J K, van Osdol W W, Monks A P, Scudiero D A, Sausville E A, Zaharevitz D W, Bunow B, Viswanadhan V N, Johnson G S, Wittes R E, Paull K D
Abstract excerpt
Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory concentration (GI50) for any single cell line is simply an index of cytotoxicity or cytostasis, but the patterns of 60 such GI50 values encode unexpectedly rich, detailed information on mechanisms of drug action and drug resistance. Each compound's...
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