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Article

Characterization and Drug Resistance Patterns of Ewing's Sarcoma Family Tumor Cell Lines

2 Dec 2013

Abstract excerpt

Despite intensive treatment with chemotherapy, radiotherapy and surgery, over 70% of patients with metastatic Ewing's Sarcoma Family of Tumors (EFT) will die of their disease. We hypothesize that properly characterized laboratory models reflecting the drug resistance of clinical tumors will facilitate the application of new therapeutic agents to EFT. To determine resistance patterns, we studied newly established...

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PMID: 24312454
DOI: 10.1371/journal.pone.0080060

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