Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma.

doi:10.1002/ijc.20816

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Article

Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma.

International journal of cancer - 20 May 2005

Ferguson Roisean E, Jackson Sharon M, Stanley Anthea J, Joyce Adrian D, Harnden Patricia, Morrison Ewan E, Patel Poulam M, Phillips Roger M, Selby Peter J, Banks Rosamonde E

Abstract excerpt

Renal cancer is one of the most chemoresistant tumor types. Using a panel of 10 established renal cancer cell lines that have not been subjected to prior drug selection, the range of functional resistance phenotypes to the tubulin-binding agents paclitaxel, vinblastine, vincristine and patupilone (epothilone B, EPO906) was determined, together with expression of P-glycoprotein (PgP), multidrug resistance...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Blotting, Western
Carcinoma, Renal Cell
Cell Line
Cell Line, Tumor
Dose-Response Relationship, Drug
Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunohistochemistry

Inhibitory Concentration 50

Kidney

Kidney Neoplasms

Membrane Transport Proteins

Multidrug Resistance-Associated Protein 2

Multidrug Resistance-Associated Proteins

Paclitaxel

Source

Open in PubMed

Identifiers

PMID: 15645438
DOI: 10.1002/ijc.20816

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