Article
Expression of the neu oncogene under the transcriptional control of the myelin basic protein gene in transgenic mice: generation of transformed glial cells.
Journal of neuroscience research - 1 Jan 1992
Hayes C, Kelly D, Murayama S, Komiyama A, Suzuki K, Popko B
Abstract excerpt
We have taken a transgenic approach in an effort to specifically transform oligodendrocytes, the myelinating glial cells of the central nervous system (CNS). Transgenic mice were generated with a DNA construct that contained the activated neu oncogene under the transcriptional control of the myel...
Topics
- Animals
- Astrocytes
- Base Sequence
- Biomarkers
- Biomarkers, Tumor
- Brain Neoplasms
- Cell Differentiation
- Cell Transformation, Neoplastic
- Gene Expression Regulation
- Genes, Synthetic
- Glioblastoma
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Transgenic