Article
Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas.
European journal of endocrinology - 1 Jun 2002
Peri Alessandro, Luciani Paola, Tonacchera Massimo, Agretti Patrizia, Baglioni-Peri Silvana, Buci Lisa, Conforti Barbara, Cioppi Federica, Biliotti Giancarlo, Serio Mario, Vitti Paolo, Chiovato Luca
Abstract excerpt
OBJECTIVE: The pathogenesis of thyroid hyperfunctioning adenomas is still only partially understood and controversy exists about the frequency of gain-of-function mutations of the TSH receptor or G(s)alpha gene, which activate the cAMP pathway. The nuclear transcription factors cAMP-responsive element binding protein (CREB) and inducible cAMP early repressor (ICER) are among the final targets of this signalling...
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