Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas.

The Journal of clinical endocrinology and metabolism - 1 Aug 2000

Persani L, Lania A, Alberti L, Romoli R, Mantovani G, Filetti S, Spada A, Conti M

Abstract excerpt

Thyrocytes largely depend on cAMP signaling for replication and differentiation. This pathway may be constitutively activated by mutations of the TSH receptor (TSHR) and Gsalpha in autonomous thyroid adenomas (ATAs). Because steady state cAMP results from production by adenylyl cyclase and degradation by phosphodiesterases (PDEs), we evaluated PDE activity and expression in ATAs with wild-type and mutant TSHR and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Isoenzymes

Share to Phosphoric Diester Hydrolases

Share to Receptors, Thyrotropin

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 10946896
DOI: 10.1210/jcem.85.8.6712

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas.PMID 10946896Read ↗

Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesisSemantic proximity Read ↗

Enhanced functional activity in thyroid adenomas in vitro.Semantic proximity Read ↗

cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumorsSemantic proximity Read ↗

Mutation analysis of the Epac--Rap1 signaling pathway in cold thyroid follicular adenomas.Semantic proximity Read ↗

The 3',5'-cyclic adenosine monophosphate response element binding protein (CREB) is functionally reduced in human toxic thyroid adenomas.Semantic proximity Read ↗

Autonomously functioning thyroid nodules in a former iodine-deficient area commonly harbor gain-of-function mutations in the thyrotropin signaling pathway.Semantic proximity Read ↗

Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid.Semantic proximity Read ↗

Thyrotropin receptor: a role for thyroid tumourigenesis?Semantic proximity Read ↗

Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas.Semantic proximity Read ↗

Activation of the cAMP cascade in thyroid autonomy.Semantic proximity Read ↗

Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules.Semantic proximity Read ↗

Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.