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Article

Mutational specificity of the anti 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene.

Carcinogenesis - 1 Dec 1990

Bigger C A, Flickinger D J, Strandberg J, Pataki J, Harvey R G, Dipple A

Abstract excerpt

An SV40-based pS189 shuttle vector, which contained a supF target gene and was replicated in human cells (Ad293), was used to determine the mutational specificity of anti 5-methylchrysene 1,2-dihydrodiol 3,4-epoxide, the active metabolite of the environmentally prevalent carcinogen 5-methylchrysene. The frequency of supF mutants containing point mutations increased with dose to approximately 40 times the...

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PMID: 2176139
DOI: 10.1093/carcin/11.12.2263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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