Article
Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.
Archives of biochemistry and biophysics - 15 Jul 2008
Kranendonk Michel, Marohnic Christopher C, Panda Satya P, Duarte Maria Paula, Oliveira José Santos, Masters Bettie Sue Siler, Rueff José
Abstract excerpt
Y459H and V492E mutations of cytochrome P450 reductase (CYPOR) cause Antley-Bixler syndrome due to diminished binding of the FAD cofactor. To address whether these mutations impaired the interaction with drug-metabolizing CYPs, a bacterial model of human liver expression of CYP1A2 and CYPOR was implemented. Four models were generated: POR(null), POR(wt), POR(YH), and POR(VE), for which equivalent CYP1A2 and CYPOR...
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