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Article

Photochemical genotoxicity and photochemical carcinogenesis--two sides of a coin?

Toxicology letters - 28 Dec 1998

Müller L, Kasper P, Kersten B, Zhang J

Abstract excerpt

The direct tumorigenic effects of ultraviolet radiation (UVR) are well known. Specifically, the premutagenic lesions of UVB (290-320 nm), are known to be the most important molecular events in UVR tumorigenicity. The less carcinogenic UVA (320-400 nm) mainly generates oxidative damage in the DNA via photodynamic generation of active oxygen species involving endogenous or exogenous photosensitizers. Several...

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PMID: 10022283
DOI: 10.1016/s0378-4274(98)00236-7

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