Genetically modified Chinese hamster ovary (CHO) cells for studying the genotoxicity of heterocyclic amines from cooked foods.

doi:10.1016/0378-4274(95)03527-3

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Article

Genetically modified Chinese hamster ovary (CHO) cells for studying the genotoxicity of heterocyclic amines from cooked foods.

Toxicology letters - 1 Dec 1995

Thompson L H, Wu R W, Felton J S

Abstract excerpt

We have developed metabolically competent Chinese hamster ovary (CHO) cells to evaluate the genotoxicity associated with heterocyclic amines, such as those that are present in cooked foods. Into repair-deficient UV5 cells we introduced cDNAs for expressing cytochrome P450IA2 and acetyltransferase...

Topics

Animals
Biotransformation
CHO Cells
Cricetinae
Cytochrome P-450 Enzyme System
Imidazoles
Mutagens
Mutation
Quinolines

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