Article
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
Cancer research - 1 Apr 1992
Giaccone G, Gazdar A F, Beck H, Zunino F, Capranico G
Abstract excerpt
Patterns of drug sensitivities in relation to topoisomerase II gene expression and activity were studied in eight human lung cancer cell lines not selected in vitro for drug resistance. The cytotoxicities of doxorubicin, etoposide, teniposide, cisplatin, camptothecin, and 5-fluorouracil were measured and, remarkably, these unselected cell lines were shown to have a common pattern of multidrug sensitivity, i.e., a...
Topics
- Adenocarcinoma
- Antineoplastic Agents
- Blotting, Northern
- Blotting, Southern
- Camptothecin
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Cell Line
- Cell Survival
- Cisplatin
- DNA Topoisomerases, Type II