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Article

Characterization of an etoposide-resistant human small-cell lung cancer cell line.

Cancer chemotherapy and pharmacology - 1 Jan 1990

Minato K, Kanzawa F, Nishio K, Nakagawa K, Fujiwara Y, Saijo N

Abstract excerpt

We established an etoposide (VP-16)-resistant human small-cell lung cancer cell line (H69/VP) by stepwise exposure to VP-16. The resistance of H69/VP to VP-16 was 9.4-fold that of the parent cell line (H69/P). H69/VP showed cross-resistance to Adriamycin (ADM), (4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidinopiperidino) carbonyloxy]-1H-pyrano[3',4':6,7]indolizino [1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Carcinoma, Small Cell
DNA Topoisomerases, Type II
Drug Resistance
Etoposide
Humans
Lung Neoplasms
Membrane Glycoproteins
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

RNA, Neoplasm

Tumor Cells, Cultured

Source

Identifiers

PMID: 1976450
DOI: 10.1007/BF02897284

Genes

ADM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1976450-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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