Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells

doi:10.1158/1535-7163.327.3.3

Article

Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells

1 Mar 2004

Abstract excerpt

Overexpression of the anti-apoptotic protein Bcl-2 has been associated with several malignancies, including small cell lung cancer (SCLC). In the present study, we have investigated if Bcl-2 contributes to the emergence of cisplatin resistance in SCLC H69 cells. The ability of cisplatin to induce apoptosis was decreased in H69 cells that acquired resistance to cisplatin (H69/CP). The level of Bcl-2 was, however,...

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