Article
Myogenesis and MyoD down-regulate Sp1. A mechanism for the repression of GLUT1 during muscle cell differentiation.
The Journal of biological chemistry - 16 May 1997
Viñals F, Fandos C, Santalucia T, Ferré J, Testar X, Palacín M, Zorzano A
Abstract excerpt
Muscle cell differentiation caused a reduction of glucose transport, GLUT1 glucose transporter expression, and GLUT1 mRNA levels. A fragment of 2.1 kilobases of the rat GLUT1 gene linked to chloramphenicol acetyltransferase drove transcriptional activity in myoblasts, and differentiation caused a...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Differentiation
- Cells, Cultured
- Gene Expression Regulation
- Glucose Transporter Type 1
- Molecular Sequence Data
- Monosaccharide Transport Proteins
- Muscle, Skeletal
- Mutation
- MyoD Protein
- Nuclear Proteins
- Rats
- Recombinant Proteins