Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation.

doi:10.1038/360477a0

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Article

Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation.

Nature - 3 Dec 1992

Song K, Wang Y, Sassoon D

Abstract excerpt

The terminal differentiation of myogenic cells initiates in the proximal portion of the limb bud whereas the distal region remains undifferentiated and proliferative. The apical ectodermal ridge maintains the progress zone in an undifferentiated state and induces proliferation of limb mesenchymal cells. Hox-7.1, a homeobox-containing gene, is expressed throughout the limb bud when limb outgrowth begins, whereas...

Topics

Actins
Animals
Blotting, Northern
Cell Differentiation
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Genes, Homeobox
Mice
Mice, Nude
Muscle Proteins
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MyoD Protein

Nuclear Proteins

Phenotype

Phosphoproteins

RNA, Messenger

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1360150
DOI: 10.1038/360477a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1360150-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation.PMID 1360150Read ↗

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