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Article

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1 Oct 1992

Abstract excerpt

The E6 proteins of the high-risk human papillomaviruses (HPVs) have been shown to form a complex with and induce the degradation of human p53 in vitro. To determine whether p53 is degraded more rapidly in cells expressing E6 in vivo, the half-life of p53 was determined by pulse-chase analysis in early-passage normal human keratinocytes and fibroblasts, human keratinocytes immortalized with HPV type 16 (HPV16) E6...

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PMID: 1326671
DOI: 10.1128/jvi.66.10.6237-6241.1992

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Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytesPMID 1326671Read ↗

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