Article

A critical role for E2-p53 interaction during the HPV16 life cycle

2021-11-02

Abstract excerpt

Human papillomaviruses (HPV) are causative agents in ano-genital and oral cancers; HPV16 is the most prevalent type detected in human cancers. The HPV16 E6 protein targets p53 for proteasomal degradation to facilitate proliferation of the HPV16 infected cell. However, in HPV16 immortalized cells E6 is predominantly spliced (E6*) and unable to degrade p53. Here we demonstrate that human foreskin keratinocytes immor...

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Literature Corpus work: e7a2acde-b0ba-5756-9f45-f9a12daf0fae
DOI: 10.1101/2021.11.01.466861

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