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Article

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 Dec 1990

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 2175676
DOI: 10.1016/0092-8674(90)90409-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53PMID 2175676Read ↗

Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6Semantic proximity Read ↗

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activationSemantic proximity Read ↗

Novel Functions of the Human Papillomavirus E6 OncoproteinsSemantic proximity Read ↗

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription.Semantic proximity Read ↗

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradationSemantic proximity Read ↗

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve OncogenesisSemantic proximity Read ↗

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.Semantic proximity Read ↗

The role of human papillomavirus oncoproteins E6 and E7 in apoptosisSemantic proximity Read ↗

Stabilization and Functional Impairment of the Tumor Suppressor p53 by the Human Papillomavirus Type 16 E7 OncoproteinSemantic proximity Read ↗

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.Semantic proximity Read ↗

Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: Roles of E6 and E7 proteinsSemantic proximity Read ↗

Covalent Inhibition of the Human Papillomavirus Type 16 E6 Protein Restores p53 and Suppresses HPV-Driven TumorigenesisSemantic proximity Read ↗

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