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Article

Telomerase activation by the E6 gene product of human papillomavirus type 16.

Nature - 7 Mar 1996

Klingelhutz A J, Foster S A, McDougall J K

Abstract excerpt

Activation of telomerase, a ribonucleoprotein complex that synthesizes telomere repeat sequences, is linked to cell immortalization and is characteristic of most cell lines and tumours. Here we show that expression of the human papillomavirus type 16 (HPV-16) E6 protein activates telomerase in early-passage human keratinocytes and mammary epithelial cells. This activation was observed in cells pre-crisis, that...

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Identifiers

PMID: 8598912
DOI: 10.1038/380079a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Telomerase activation by the E6 gene product of human papillomavirus type 16.PMID 8598912Read ↗

The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Dissociate Cellular Telomerase Activity from the Maintenance of Telomere LengthSemantic proximity Read ↗

E Box-Dependent Activation of Telomerase by Human Papillomavirus Type 16 E6 Does Not Require Induction of c- mycSemantic proximity Read ↗

Cell-Restricted Immortalization by Human Papillomavirus Correlates with Telomerase Activation and Engagement of the hTERT Promoter by MycSemantic proximity Read ↗

Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human KeratinocytesSemantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 OncoproteinSemantic proximity Read ↗

Telomerase Induction in HPV Infection and OncogenesisSemantic proximity Read ↗

The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.Semantic proximity Read ↗

Modulation of basal cell fate during productive and transforming HPV‐16 infection is mediated by progressive E6‐driven depletion of NotchSemantic proximity Read ↗

HPV16 E7 Protein and hTERT Proteins Defective for Telomere Maintenance Cooperate to Immortalize Human KeratinocytesSemantic proximity Read ↗

HPV E6 protein interacts physically and functionally with the cellular telomerase complexSemantic proximity Read ↗

E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescenceSemantic proximity Read ↗

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