Article
Intracellular adenosine 3',5'-phosphate formation is essential for down-regulation of surface adenosine 3',5'-phosphate receptors in Dictyostelium.
The Biochemical journal - 15 Oct 1994
Van Haastert P J
Abstract excerpt
Dictyostelium discoideum cells contain cell surface cyclic AMP (cAMP) receptors that bind cAMP as a first messenger and intracellular cAMP receptors that bind cAMP as a second messenger. Prolonged incubation of Dictyostelium cells with cAMP induces a sequential process of phosphorylation, sequest...
Topics
- Animals
- Binding Sites
- Caffeine
- Cell Membrane Permeability
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Dictyostelium
- Down-Regulation
- Enzyme Activation
- Membrane Proteins
- Mutation
- Nucleotides, Cyclic
- Receptors, Cyclic AMP
- Thionucleotides