Article
Mutations causing aminotriazole resistance and temperature sensitivity reside in gyrB, which encodes the B subunit of DNA gyrase.
Journal of bacteriology - 1 Aug 1992
Toone W M, Rudd K E, Friesen J D
Abstract excerpt
Certain mutations in gyrA and gyrB, the genes encoding the two subunits of DNA gyrase, are known to influence expression of the his operon (K. E. Rudd and R. Menzel, Proc. Natl. Acad. Sci. USA 84:517-521, 1987). Such mutations lead to a decrease in tRNA(His) levels and consequently to an attenuator-dependent increase in his operon expression. This effect presumably is due to the dependence of the hisR promoter...
Topics
- Amitrole
- Chromosome Mapping
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Escherichia coli
- Genes, Bacterial
- Mutation
- Operon
- Phenotype
- Promoter Regions, Genetic
- RNA, Transfer, His