Article
Common sequence determinants of the response of a prokaryotic promoter to DNA bending and supercoiling.
The EMBO journal - 1 Apr 1991
Figueroa N, Wills N, Bossi L
Abstract excerpt
Inhibiting the activity of DNA gyrase by mutation or by drugs in S. typhimurium causes the loss of transcription attenuation in the histidine operon. We show that gyrase activity is needed to maintain high-level expression of the tRNA(His) gene (hisR), a prerequisite for proper functioning of the...
Topics
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA Topoisomerases, Type II
- DNA, Bacterial
- DNA, Superhelical
- Genes, Bacterial
- Genotype
- Molecular Sequence Data
- Mutation
- Operon
- Plasmids
- Promoter Regions, Genetic
- RNA, Transfer, His
- Restriction Mapping
- Salmonella typhimurium
- Transduction, Genetic