Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.

Molecular and cellular biology - 1 Mar 1992

Lim S K, Sigmund C D, Gross K W, Maquat L E

Abstract excerpt

Human beta zero-thalassemic beta-globin genes harboring either a frameshift or a nonsense mutation that results in the premature termination of beta-globin mRNA translation have been previously introduced into the germ line of mice (S.-K. Lim, J.J. Mullins, C.-M. Chen, K. Gross, and L.E. Maquat, EMBO J. 8:2613-2619, 1989). Each transgene produces properly processed albeit abnormally unstable mRNA as well as...

Topics

Alleles
Animals
Base Sequence
Blotting, Northern
Cloning, Molecular
Codon
DNA
Globins
Humans
Kinetics
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

RNA Precursors

RNA, Messenger

Terminator Regions, Genetic

Thalassemia

Source

Open in PubMed Open full text

Identifiers

PMID: 1545796
DOI: 10.1128/mcb.12.3.1149-1161.1992
PMCID: PMC369546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1545796-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.PMID 1545796Read ↗

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.Semantic proximity Read ↗

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.Semantic proximity Read ↗

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.Semantic proximity Read ↗

Abnormally spliced β-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decaySemantic proximity Read ↗

Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: a mechanism for the phenotype of dominant beta-thalassemia.Semantic proximity Read ↗

Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?Semantic proximity Read ↗

Lost in Translation: Ribosome-Associated mRNA and Protein Quality ControlsSemantic proximity Read ↗

mRNA Metabolism and hereditary disorders: a tale of surveillance and escape.Semantic proximity Read ↗

Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region.Semantic proximity Read ↗

Role of nonsense-mediated decay and nonsense-associated altered splicing in the mRNA pattern of two new α-thalassemia mutants.Semantic proximity Read ↗

Nonsense Mutations in hERG Cause a Decrease in Mutant mRNA Transcripts by Nonsense-Mediated mRNA Decay in Human Long-QT SyndromeSemantic proximity Read ↗

Cytoplasmic nonsense-mediated mRNA decay for a nonsense (W262X) transcript of the gene responsible for hereditary tyrosinemia, fumarylacetoacetate hydrolase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.