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Article

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.

Molecular and cellular biology - 1 Mar 1992

Lim S K, Sigmund C D, Gross K W, Maquat L E

Abstract excerpt

Human beta zero-thalassemic beta-globin genes harboring either a frameshift or a nonsense mutation that results in the premature termination of beta-globin mRNA translation have been previously introduced into the germ line of mice (S.-K. Lim, J.J. Mullins, C.-M. Chen, K. Gross, and L.E. Maquat, EMBO J. 8:2613-2619, 1989). Each transgene produces properly processed albeit abnormally unstable mRNA as well as...

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Identifiers

PMID: 1545796
DOI: 10.1128/mcb.12.3.1149-1161.1992
PMCID: PMC369546

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