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The use of engineered E1A genes to transactivate the hCMV-MIE promoter in permanent CHO cell lines

1 Jan 1991

Abstract excerpt

Vectors expressing adenovirus 5 E1A or a domain 2 mutant E1A were introduced into CHO-K1 cells in order to transactivate the hCMV-MIE promoter in transient and stable transfections. Expression from the hCMV promoter was efficiently activated by both wild-type and mutant E1A in contrast to other viral promoters such as the SV40 early promoter which are repressed by E1A. E1A genes expressed from a strong promoter...

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PMID: 1707522
DOI: 10.1093/nar/19.2.319

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