Article
Coexpression of stromelysin-3 and insulin-like growth factor II in tumors of ectodermal, mesodermal, and endodermal origin: indicator of a fetal cell phenotype.
The Journal of clinical endocrinology and metabolism - 1 Jun 1997
Singer C F, Rasmussen A, Lippman M E, Cullen K J
Abstract excerpt
Stromelysin-3 (ST-3) is thought to play an important role in invasion and tumor progression. We have analyzed ST-3 expression in fibroblasts with defined topographical relations to breast cancers. We demonstrate that these fibroblasts exhibit the same distinctive pattern of messenger ribonucleic...
Topics
- Breast Neoplasms
- Colonic Neoplasms
- Female
- Fetus
- Fibroblasts
- Humans
- Immunohistochemistry
- Insulin-Like Growth Factor II
- Matrix Metalloproteinase 11
- Metalloendopeptidases
- Neoplasm Invasiveness
- Phenotype
- RNA, Messenger
- Sarcoma
- Skin
- Tumor Cells, Cultured